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Alpha-1-Antichymotrypsin

Alpha-1 Antichymotrypsin (ACT) is an acute phase protein synthesised in the liver. Within the human body it inhibits the activity of proteases such as cathepsin by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. ACT has a number of different uses in clinical diagnostics. Elevated serum levels of ACT are seen during inflammation and reduced serum levels have been associated with liver disease. It has also been associated with the pathogenesis of Alzheimer’s disease as it enhances the formation of amyloid-fibrils in this disease. Within the human body ACT binds with Prostate specific antigen (PSA) to for a PSA-ACT complex. This is used as an indicator of tumor mass and clinical stage of prostate cancer.

Abbreviation ACT
Molecular Weight 55 - 68 kDa

Variants (Click plus sign to expand variant information)

  Variant Name Product Code Purity
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 Alpha-1-Antichymotrypsin, ultra pure P159-0 Ultra Pure
 
Purity Ultra Pure
Specification > 99% pure
Source Human Serum
Presentation Lyophilized
Reconstitution Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended. To ensure full product recovery, it is advised that reconstitution is performed directly into supplied vial incorporating further washings with the reconstitution buffer.
Health and Safety Starting material tested for HIV 1 & 2 Antibodies, Hepatitis B Surface Antigen Hepatitic C Virus Antibodies and Hepatitis B Core Antibodies. No test can guarantee the absence of an infectious agent. Please handle as potentially hazardous.
Minimum Order 1 mg
Storage Temperature 2 - 8°C
Shipping Recommendation Cool Pack
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+
 Alpha-1-Antichymotrypsin, pure P159-5 Pure
 
Purity Pure
Specification > 90% pure
Source Human Serum
Presentation Lyophilized
Reconstitution Use of deionized is recommended. To ensure full product recovery, it is advised that reconstitution is performed directly into supplied vial incorporating further washings with the reconstitution buffer.
Health and Safety Starting material tested for HIV 1 & 2 Antibodies, Hepatitis B Surface Antigen Hepatitic C Virus Antibodies and Hepatitis B Core Antibodies. No test can guarantee the absence of an infectious agent. Please handle as potentially hazardous.
Minimum Order 1 mg
Storage Temperature 2 - 8°C
Shipping Recommendation Cool Pack
View Typical Certificate of Analysis
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