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Alpha-2-Macroglobulin

Alpha-2 macroglobulin is a tetrameric glycoprotein synthesised in the liver and also locally by macrophages, fibroblasts, and adrenocortical cells. It is a serine proteases inhibitor; it inhibits coagulation by inactivating thrombin and kallikrein and inhibits fibrinolysis by inactivating plasmin. It also acts as a carrier protein as it binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor and insulin. Alpha-2-macroglobulin levels are increased in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. Levels are also elevated with cirrhosis, pregnancy and diabetes.

Abbreviation A2M, α2M
Synonyms α2-macroglobulin
Molecular Weight 720 kDa

Variants (Click plus sign to expand variant information)

  Variant Name Product Code Purity
+
 Alpha-2-Macroglobulin, highly pure P144-5 Highly Pure
 
Purity Highly Pure
Specification > 96% pure
Source Human Serum
Presentation Lyophilized
Reconstitution Use of deionized is recommended. To ensure full product recovery, it is advised that reconstitution is performed directly into supplied vial incorporating further washings with the reconstitution buffer.
Health and Safety Starting material tested for HIV 1 & 2 Antibodies, Hepatitis B Surface Antigen Hepatitic C Virus Antibodies and Hepatitis B Core Antibodies. No test can guarantee the absence of an infectious agent. Please handle as potentially hazardous.
Minimum Order 2 mg
Storage Temperature 2 - 8°C
Shipping Recommendation Cool Pack
View Typical Certificate of Analysis
View MSDS
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