Alpha Fetoprotein (AFP) is a major plasma protein produced by the yolk sac and the liver during foetal development. It is thought to be the foetal form of serum albumin. The highest levels of AFP are found in the human foetus. Foetal serum levels decrease after the first trimester and almost completely disappear from both mother and child a few weeks after birth. Normal adult levels are usually achieved by the age of 8 to 12 months. The function of AFP in adults is unknown, however in foetuses it binds estradiol to prevent the transport of this hormone across the placenta. AFP is measured in pregnant women through the analysis of maternal blood or amniotic fluid, as a screening test for open neural tube defects and Down syndrome. Assays of AFP are also used in the diagnosis and monitoring of hepatocellular carcinoma and testicular cancer.
| Abbreviation | AFP |
| Synonyms | alpha-1-fetoprotein, α-fetoprotein, alpha-fetoglobulin |
| Molecular Weight | 63 - 68 kDa |
| Variant Name | Product Code | Purity | |
|---|---|---|---|
+ |
Alpha Fetoprotein, concentrate | P109-2 | Concentrate |
+ |
Alpha Fetoprotein, ultra pure | P109-3 | Ultra Pure |
