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Beta-2-Microglobulin

Beta-2-Microglobulin is a blood plasma protein found in all nucleated cells. One of its functions is to regulate endocytosis of iron into intestinal cells. Loss of this function causes iron excess and hemochromatosis. In patients on long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces, a disease known as dialysis-related amyloidosis. Levels of B2M in the serum can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). In clinical diagnostics it is most widely used to evaluate the severity and prognosis of multiple myeloma, leukaemia, or lymphoma and to distinguish between kidney disorders and to detect kidney damage.

Abbreviation B2M, β2M
Synonyms β2 Microglobulin
Molecular Weight 12 kDa

Variants (Click plus sign to expand variant information)

  Variant Name Product Code Purity
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 Beta-2-Microglobulin, standard grade P122-2 Standard
 
Purity Standard
Specification > 40% pure
Source Human Urine from Chronic Renal Tubular Proteinuria Patients
Presentation Lyophilized
Reconstitution Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended. To ensure full product recovery, it is advised that reconstitution is performed directly into supplied vial incorporating further washings with the reconstitution buffer.
Health and Safety Starting material tested for HIV 1 & 2 Antibodies, Hepatitis B Surface Antigen Hepatitic C Virus Antibodies and Hepatitis B Core Antibodies. No test can guarantee the absence of an infectious agent. Please handle as potentially hazardous.
Minimum Order 2 mg
Storage Temperature 2 - 8°C
Shipping Recommendation Cool Pack
View Typical Certificate of Analysis
View MSDS
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+
 Beta-2-Microglobulin, highly pure P122-1 Highly Pure
 
Purity Highly Pure
Specification > 98% pure
Source Human Urine from Chronic Renal Tubular Proteinuria Patients
Presentation Lyophilized
Reconstitution Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended. To ensure full product recovery, it is advised that reconstitution is performed directly into supplied vial incorporating further washings with the reconstitution buffer.
Health and Safety Starting material tested for HIV 1 & 2 Antibodies, Hepatitis B Surface Antigen Hepatitic C Virus Antibodies and Hepatitis B Core Antibodies. No test can guarantee the absence of an infectious agent. Please handle as potentially hazardous.
Minimum Order 2 mg
Storage Temperature 2 - 8°C
Shipping Recommendation Cool Pack
Buy from SunnyLab